Search results for "Antigen delivery"

showing 2 items of 2 documents

Could allergen-specific immunotherapy benefit from the use of nanocarriers?

2016

Allergen-specific immunotherapy: challenges The total number of people suffering from allergic diseases increased dramatically during recent decades. Allergic reactions of the immediate type (type I hypersensitivity reactions according to classification by Coombs and Gell) involve an overreaction of the immune system and the formation of IgE

0301 basic medicinemedicine.medical_treatmentBiomedical EngineeringMedicine (miscellaneous)BioengineeringDevelopmentImmunoglobulin E03 medical and health sciencesDrug Delivery Systems0302 clinical medicineImmune systemmedicineHumansGeneral Materials ScienceAntigen deliverybiologybusiness.industrySpecific immunotherapyImmunotherapyAllergensmedicine.diseaseNanomedicine030104 developmental biology030228 respiratory systemDesensitization ImmunologicImmunologybiology.proteinNanoparticlesNanocarriersbusinessType I hypersensitivityNanomedicine
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Carbon nanotube-protein carriers enhance size-dependent self-adjuvant antibody response to haptens

2013

Carbon nanotubes (CNTs) are nanomaterials with interesting emerging applications. Their properties make CNTs excellent candidates for use as new nanovehicles in drug delivery, immunization and diagnostics. In the current study, we assessed the immune-response-amplifying properties of CNTs to haptens by using azoxystrobin, the first developed strobilurin fungicide, asamodel analyte. Anazoxystrobin derivative bearingacarboxylated spacer arm (hapten AZc6) was covalently coupled to bovine serum albumin (BSA), and the resulting BSA-AZc6 conjugate was covalently linked to four functionalized CNTs of different shapes and sizes, varying in diameter and length. These four types of CNT-based construc…

Analytemedicine.medical_treatmentAzoxystrobinFreund's AdjuvantAntigen deliveryCarbon nanotubesPharmaceutical ScienceAntibodiesBiomaterialsMicechemistry.chemical_compoundMicroscopy Electron TransmissionmedicineAnimalsOrganic chemistryBovine serum albuminDrug CarriersMice Inbred BALB CbiologyNanotubes CarbonChemistrySerum Albumin BovineStrobilurinsFungicides IndustrialPyrimidinesAzoxystrobinImmunoglobulin GDrug deliverybiology.proteinBiophysicsMethacrylatesFemaleImmunizationRabbitsAntibodyHaptensAdjuvantHaptenConjugate
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